Dysfunction of T cell receptor AV24AJ18+,BV11+ double‐negative regulatory natural killer T cells in autoimmune diseases
نویسندگان
چکیده
منابع مشابه
Targeting T regulatory cells in autoimmune diseases.
Among the several mechanisms that play a role in maintaining peripheral self-tolerance is the existence of a unique CD4+CD25+ population of naturally occurring regulatory T cells, which actively prevent both the activation and the effector function of autoreactive T cells that have escaped different mechanisms of tolerance. Many studies have shown the benefit of targeting this cell population b...
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The regulatory T (Treg) cells play an important role in the maintenance of homeostasis and the prevention of autoimmune diseases. Although most studies are focusing on the role of Treg cells in T cells and T cells-mediated diseases, these cells also directly affect B cells and other non-T cells. This manuscript updates the role of Treg cells on the B cells and B cell-mediated diseases. In addit...
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Abstract Natural killer (NK) T cells emerge as unique lymphocytes subsets implicated in the regulation of autoimmunity. Abnormalities in the numbers and functions of NKT cells have been observed in patients with diverse autoimmune diseases as well as in a variety of mouse strains that are genetically predisposed for the development of autoimmune diseases. Unlike conventional T cells that recogn...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 2001
ISSN: 0004-3591,1529-0131
DOI: 10.1002/1529-0131(200105)44:5<1127::aid-anr194>3.3.co;2-n